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KMID : 0545120090190060629
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 6 p.629 ~ p.633
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Suppression of Metastasis of Human Breast Cancer Cells by Chitosan Oligosaccharides
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Nam Kyung-Soo
Shon Yun-Hee
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Abstract
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The present study investigated the antimetastatic property of chitosan oligosaccharides (COS) by evaluating motility, invasion, and the amount and activity of MMP-9 in MDA-MB-231 human breast carcinoma cells. Treatment of MDA-MB-231 cells with increasing concentrations of COS led to a concentration-dependent decrease in cell migration. COS significantly inhibited the invasion of MDA-MB-231 cells through a Matrigel-coated membrane. The treatment of MDA-MB-231 cells with COS reduced the amounts of secreted MMP-9. The activity and amount of MMP-9 protein in MDA-MB-231 cells were decreased by treatment with COS and occurred in a concentrationdependent manner. Our data indicated that COS can serve as a potential novel therapeutic candidate for the treatment of metastatic breast cancer.
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KEYWORD
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Breast cancer, chitosan oligosaccharides, invasion, metastasis, matrix metalloproteinase
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